CYTOKINES AND THE CHRONIC INFLAMMATION OF RHEUMATIC DISEASE .1. THE PRESENCE OF INTERLEUKIN-1 IN SYNOVIAL-FLUIDS
- 1 January 1984
- journal article
- research article
- Vol. 55 (2), 295-302
Abstract
Synovial fluids from patients with rheumatoid arthritis (13 cases), ankylosing spondylitis (6), psoriatic arthritis (2), osteoarthritis (3) and rubella arthritis (4) contain interleukin I (II-1) activity as measured in the CH3/He mouse thymocyte assay. That this activity is II-1 was shown by the time course of thymocyte stimulation; failure of PHA [phytohemagglutinin] blast cells to absorb out the activity; MW of 15,000-20,000 daltons, and ability to stimulate prostaglandin E2 production from synovial cells. IL-1 is an important mediator in the inflammatory pathway of different types of joint disease.This publication has 14 references indexed in Scilit:
- Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritisRheumatology International, 1982
- The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogenCellular Immunology, 1981
- Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.Journal of Clinical Investigation, 1981
- Purification of a factor from human blood monocyte‐macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissuesFEBS Letters, 1981
- Studies on the role of lymphocyte-activating factor (Interleukin 1) in antigen-induced lymph node lymphocyte proliferationCellular Immunology, 1980
- CHARACTERIZATION OF LYMPHOCYTE-ACTIVATING FACTOR (LAF) PRODUCED BY A MACROPHAGE CELL LINE, P388D1 .2. BIOCHEMICAL CHARACTERIZATION OF LAF INDUCED BY ACTIVATED T-CELLS AND LPS1978
- Association of a Low Molecular Weight Helper Factor(s) with Thymocyte Proliferative ActivityThe Journal of Immunology, 1977
- Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells.The Journal of Experimental Medicine, 1977
- POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENSThe Journal of Experimental Medicine, 1972
- “Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte ActivationNature, 1969