Ventilatory Response to Hypercapnia in Normal Subjects after Propranolol, Metoprolol and Oxprenolol

Abstract

Steady state ventilatory response curves to CO₂ were taken in 8 normal subjects in control situations and taking clinical doses of propranolol, oxprenolol and metoprolol in a double-blind crossover design. Furthermore, the expiratory peak flow was measured. No effect was found of any of the β-blockers on the resting ventilatory parameters, the sensitivity to CO₂ or the peak flow values