Serotonin Receptor Modulation by Estrogen in Discrete Brain Nuclei
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 35 (4), 287-291
- https://doi.org/10.1159/000123396
Abstract
The effect of estradiol on serotonin (5HT1) receptors of ovariectomized female rats was studied in discrete brain nuclei by a micro-binding assay and quantitative autoradiography. The 2 methods show similar distribution of the 5HT1 receptor and estradiol significantly increases the density of receptors in the preoptic area, anterior hypothalamus, lateral septum and arcuate-median eminence. The increase 5HT1 receptors in these particular nuclei may be related to estrogen control of ovulation and/or other estrogen-mediated central phenomena.This publication has 3 references indexed in Scilit:
- Localized Behavioral Effects of Tritiated Estradiol Implants in the Ventromedial Hypothalamus of Female Rats*Endocrinology, 1979
- CHARACTERISTICS OF CENTRAL 5-HT RECEPTORS AND THEIR ADAPTIVE-CHANGES FOLLOWING INTRA-CEREBRAL 5,7-DIHYDROXYTRYPTAMINE ADMINISTRATION IN THE RAT1978
- SEROTONIN AND LYSERGIC-ACID DIETHYLAMIDE BINDING IN RAT-BRAIN MEMBRANES - RELATIONSHIP TO POSTSYNAPTIC SEROTONIN RECEPTORS1976