CHANGES IN PLASMA-GLUCOSE, INSULIN AND GLUCAGON-LEVELS, GLUCOSE-TOLERANCE TESTS AND INSULIN SENSITIVITY WITH AGE IN THE RAT
- 1 January 1980
- journal article
- research article
- Vol. 6 (2), 135-139
Abstract
Glucose and insulin relationships with aging were studied in fed rats. Levels of basal circulating glucose did not change while those of RIA[radioimmunoassay]-insulin increased and RIA-glucagon decreased linearly with animal weight. The oral glucose tolerance test revealed a greater increase in blood glucose in adult and old rats than in prepuberals, while the rise in plasma insulin was faster and greater in the oldest group. After i.v. glucose load, plasma insulin increase was greater in adult than in prepuberal and old rats, and in the latter group values remained elevated for a longer period. The hypoglycemic response to i.v. insulin was greatest in the prepuberals with no difference between adult and old rats. In prepuberals, the augmented insulin sensitivity was counteracted by retarded insulinotropic glucose action and an enhanced basal glucagon level, while in the old animals normoglycemia was maintained due to an augmented secretory response of B cells, counteracted by reduced sensitivity to endogenous insulin.This publication has 9 references indexed in Scilit:
- The effect of age on insulin-degrading activity in rat tissueDiabetes, 1979
- Pancreatic Beta Cell Secretion during Oral and Intravenous Glucose AdministrationActa Medica Scandinavica, 1979
- Insulin and glucagon relationships during aging in manMetabolism, 1977
- Plasma glucagon in pups, decreased by fasting, unaffected by somatostatin or hypoglycemiaAmerican Journal of Physiology-Legacy Content, 1976
- Effect of ageing on insulin and insulin-glucose sensitivity tests in ratsActa Diabetologica, 1975
- GLUCOSE TOLERANCE, AGE, AND CIRCULATING INSULINThe Lancet, 1967
- Glucose Tolerance, Plasma Insulin, and Free Fatty Acids in Elderly SubjectsAnnals of Internal Medicine, 1966
- Reduced Glucose Tolerance in Elderly Human SubjectsDiabetes, 1965
- Immunoassay of insulin with insulin-antibody precipitateBiochemical Journal, 1963