Metabolism in normal and pancreatectomized dogs during steady-state exercise

Abstract

The rates of turnover and oxidation of plasma free fatty acids and of glucose were measured by infusing radiopalmitrate or radioglucose into normal and pancreatectomized dogs running on the treadmill. In both cases plasma free fatty acids represented the major energy supply; plasma glucose played only a minor role, smaller in diabetic man in normal dogs. When glucose utilization in the latter group was enhanced by continuous infusions of glucose, exercise shifted the metabolism from carbohydrate towards fat oxidation by increasing the concentration of plasma free fatty acids and by decreasing the plasma level of insulin.