Although there is considerable difference of opinion regarding the therapeutic efficacy of bactericidal concentrations of penicillin for a brief time as opposed to the maintenance of bacteriostatic concentrations for prolonged periods, it is not within the province of this paper to discuss the relative merits of these two approaches to penicillin therapy. Suffice it to say that there are authoritative proponents of both methods of treatment and there are good reasons for wishing to achieve very high levels, amounts measured in whole units of penicillin per cubic centimeter, and for maintenance of lower concentrations of a few hundredths to a few tenths of a unit per cubic centimeter for prolonged periods. It is the purpose of this paper to show how both of these requirements of therapy can be achieved. ORAL ADMINISTRATION OF CARINAMIDE WITH PENICILLIN GIVEN INTRAMUSCULARLY Penicillin is rapidly excreted by the