Role of the Pituitary in N-2-Fluorenyldiacetamide Carcinogenesis2

Abstract

It was demonstrated that hypophysectomy effectively prevented liver-tumor formation in male rats fed diets containing N-2-fluorenyldiacetamide (N-2-FdiAA). This prevention could not be reversed by administration of ACTH and insulin as occurs in azo-dye carcinogenesis. Hypophysectomy also inhibited ear-duct tumor formation in the N-2-FdiAA-treated animals. However, these rats developed a high incidence of tumors of harderian-gland origin. From evidence reported here, and from the results of other investigators, it is probable that fluorenamine carcinogenesis and azo-dye carcinogenesis may each be associated with different pituitary functions.