Reversal of synaptic vesicle docking at central synapses
- 1 June 1999
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 2 (6), 503-507
- https://doi.org/10.1038/9149
Abstract
We used quantitative fluorescence imaging of vesicles labeled with membrane-soluble dyes to determine rates of undocking and spontaneous exocytosis of vesicles docked to the active zone of hippocampal synapses in culture. Individual vesicles undock about once per two minutes and spontaneously exocytose about once per eight minutes. Thus, not only does undocking occur, but it is over threefold faster than spontaneous fusion.Keywords
This publication has 24 references indexed in Scilit:
- Activity-Dependent Modulation of the Rate at which Synaptic Vesicles Become Available to Undergo ExocytosisNeuron, 1998
- Synaptic vesicles retain their identity through the endocytic cycleNature, 1998
- Quantitative Ultrastructural Analysis of Hippocampal Excitatory SynapsesJournal of Neuroscience, 1997
- Heterogeneous Release Properties of Visualized Individual Hippocampal SynapsesNeuron, 1997
- Depletion and Replenishment of Vesicle Pools at a Ribbon-Type Synaptic TerminalJournal of Neuroscience, 1997
- Evidence That Vesicles on the Synaptic Ribbon of Retinal Bipolar Neurons Can Be Rapidly ReleasedNeuron, 1996
- The timing of synaptic vesicle endocytosis.Proceedings of the National Academy of Sciences, 1996
- Estimates for the pool size of releasable quanta at a single central synapse and for the time required to refill the pool.Proceedings of the National Academy of Sciences, 1995
- The kinetics of synaptic vesicle recycling measured at single presynaptic boutonsNeuron, 1993
- Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular JunctionScience, 1992