Detection of an Integrated Tetracycline Resistance Plasmid in the Chromosome of Methicillin-resistant Staphylococcus aureus
- 1 June 1986
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 132 (6), 1723-1728
- https://doi.org/10.1099/00221287-132-6-1723
Abstract
The majority of multiresistant Staphylococcus aureus strains isolated in Australian hospitals since 1970 carry a chromosomally-encoded minocycline and tetracycline resistance determinant. By using DNA-DNA hybridization, some of these multiresistant strains were shown to possess also a tetracycline resistance plasmid, equivalent to pT181, integrated into a unique site in the chromosome. By relating the hybridization data to the map of pT181, the site of integration on this plasmid was established to be between the genes for replication and tetracycline resistance.This publication has 2 references indexed in Scilit:
- The use of synthetic oligonucleotides with universal templates for rapid DNA sequencing: results with staphylococcal replicon pC221.The EMBO Journal, 1985
- Antibiotic susceptibilities and plasmid profiles of nosocomial methicillin-resistant Staphylococcus aureus: A retrospective studyJournal of Medical Microbiology, 1984