Effects of Acute Cerebellectomy on Maximal Electroshock Seizures and Anticonvulsant Efficacy of Diazepam in the Rat

Abstract

Rats were cerebellectomized 72-96 h prior to evaluation during maximum electroshock seizures and for their capacity to respond to pentylenetetrazol-induced clonic seizures. Cerebellectomized rats failed to exhibit tonic hindlimb extension, an endpoint characteristic of maximal electroshock seizures. The dose of pentylenetetrazol required to produce clonic seizures or death was not different in cerebellectomized and sham-operated controls. The anticonvulsant efficacy of diazepam, when assessed as a pentylenetetrazol antagonist, was not influenced by removal of the cerebellum. Whereas cerebellar influences may suppress seizure activity which is largely focal, seizures of more diffuse origin are not markedly influenced by cerebellar activity. It is essential that the role of the cerebellum in suppressing seizures be characterized for each kind of experimentally induced seizure process.