Pain perception and endorphine levels in cerebrospinal fluid
- 1 December 1978
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 5 (4), 359-365
- https://doi.org/10.1016/0304-3959(78)90004-0
Abstract
In 45 consecutive patients with chronic pain syndromes endorphins, fraction I of the cerebrospinal fluid and pain measures by means of electric stimulation via saline electrodes were investigated. In patients with high levels of fraction I (above median) pain threshold, PT and tolerance level, TL, in condition C (continuous stimulation increase) were found to be significantly higher than in patients with low levels of fraction I (below median). The results indicate that the endorphins are one of the physiological factors that contribute to the pain threshold and the tolerance level.Keywords
This publication has 18 references indexed in Scilit:
- Endorphins in chronic pain. I. Differences in CSF endorphin levels between organic and psychogenic pain syndromesPain, 1978
- Naloxone alters pain perception and somatosensory evoked potentials in normal subjectsNature, 1977
- Enkephalin pentapeptides — A review of current evidence for a physiological role in vertebrate neurotransmissionLife Sciences, 1977
- OPIOID PEPTIDESBritish Medical Bulletin, 1977
- Lack of effect of naloxone on pain perception in humansNature, 1976
- Opioid Peptides Endorphins in Pituitary and BrainScience, 1976
- A history of local electrical analgesiaPain, 1975
- THE PLACEBO RESPONSEJournal of Nervous & Mental Disease, 1963
- THE VARYING RESPONSE TO PAIN IN PSYCHIATRIC DISORDERS: A STUDY IN ABNORMAL PSYCHOLOGY*Psychology and Psychotherapy: Theory, Research and Practice, 1954
- STUDIES ON THE RELIEF OF PAIN BY COUNTERIRRITATIONJCI Insight, 1940