The Effect of Pancreatectomy on Lipemia, Tissue Lipidosis and Atherogenesis in Chicks
- 1 August 1951
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 4 (2), 255-261
- https://doi.org/10.1161/01.cir.4.2.255
Abstract
Following complete pancreatectomy, chicks exhibit an excessive hypercholesterolemia when fed a diet containing cholesterol plus cottonseed oil. This inordinate hypercholesterolemia is accompanied by intensified atherogenesis, compared with unoperated controls on the same diet. Dietary neutral fat is essential for these excessive cholesterolemic and atherogenic responses. The possible significance of these findings for the pathogenesis of atherosclerosis in diabetic man is discussed.Keywords
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