Multiplication and Cytopathogenicity of Herpes Simplex Virus in Cultures of Feline Renal Cells.

Abstract

The virus of herpes simplex was passed serially 20 times in cultures of feline renal cells. Multiplication of the virus was demonstrated when infectivity titers were measured in mice and in tissue culture. The adapted virus induced cytopathogenic changes in cell cultures of feline kidney, primary human amnion, human kidney, and FL cells. Several conditions which appear to influence the type of cytopathogenic change in cell cultures are discussed.