IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE
Open Access
- 1 April 1968
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 127 (4), 757-766
- https://doi.org/10.1084/jem.127.4.757
Abstract
Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.This publication has 21 references indexed in Scilit:
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