Biochemistry of Late Effects in Rat Lung after Hemithoracic Irradiation
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Acta Radiologica: Therapy, Physics, Biology
- Vol. 16 (5), 447-455
- https://doi.org/10.3109/02841867709133966
Abstract
The right hemithorax of rats was exposed to 1 kR of roentgen rays, the animals were killed at different times, and various physiologic and biochemic parameters (DNA, protein, collagen, sialic acid, lysosomal enzymes, fibrinolytic activity, peroxides and blood flow ratio between irradiated and non irradiated lung) were determined from 1 day until 11 months after irradiation. A decrease in relative blood flow was observed from 2 weeks until 11 months, a decrease in phospholipids from one to 3 months and a decrease in fibrinolytic activity from 1 day to 11 months after irradiation. At several times a decrease in sialic acid and cathepsin D was also noted. The changes are discussed with respect to the pathogenetic mechanisms of late lung damage.Keywords
This publication has 4 references indexed in Scilit:
- Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes.JCI Insight, 1976
- Rapid and sensitive determination of sphingosine bases and sphingolipids with fluorescamineAnalytical Biochemistry, 1974
- Radiation pneumonitis: A new approach to the derivation of time-dose factorsCancer, 1973
- Radiation damage to the surfactant system of the rabbit lungLife Sciences, 1970