ALLOGENEIC THYMUS GRAFTS AND THE RESTORATION OF IMMUNE FUNCTION IN IRRADIATED THYMECTOMIZED MICE
Open Access
- 1 February 1970
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 131 (2), 275-286
- https://doi.org/10.1084/jem.131.2.275
Abstract
Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunological capacity of such animals was studied.Keywords
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