Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy
Open Access
- 1 March 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (3), 388-391
- https://doi.org/10.1128/aac.11.3.388
Abstract
The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease ( acne vulgaris ) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.Keywords
This publication has 21 references indexed in Scilit:
- Properties of R Factors from Bordetella bronchisepticaAntimicrobial Agents and Chemotherapy, 1974
- Antibiotic Resistance and R Factors in Coliform Bacilli Isolated from Hospital and Domestic SewageJournal of Medical Microbiology, 1974
- Persistence and Dissemination in the Community of R-Factors of Nosocomial OriginThe Journal of Infectious Diseases, 1974
- CHEMOTHERAPY AND ANTIBIOTIC-RESISTANCE TRANSFER BETWEEN ENTEROBACTERIA IN THE HUMAN GASTRO-INTESTINAL TRACTJournal of Medical Microbiology, 1973
- Effect of Oral Tetracycline on the Occurrence of Tetracycline-Resistant Strains of Escherichia coli in the Intestinal Tract of HumansAntimicrobial Agents and Chemotherapy, 1973
- An Epidemic-Associated Episome?The Journal of Infectious Diseases, 1972
- R Factors in Hospital InfectionBMJ, 1972
- Preliminary observations on the occurrence of a streptomycin r-factor in mycobacterium smegmatis ATCC 607Tubercle, 1972
- R FACTORS IN ESCHERICHIA COLI IN FÆCES AFTER ORAL CHEMOTHERAPY IN GENERAL PRACTICEThe Lancet, 1971
- A CLINICAL TRIAL OF TETRACYCLINE IN ROSACEA.*British Journal of Dermatology, 1966