Short-Term Inhalation Toxicity of Halogenated Hydrocarbons
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 30 (1), 26-31
- https://doi.org/10.1080/00039896.1975.10666628
Abstract
Male rats, fasted overnight (18 hours), and exposed to various materials by inhalation were more sensitive to the hepatotoxic effects of carbon tetrachloride, 2-chlorobutadiene, 1,1-dibromoethylene, and 1,1-dichloroethylene (DCE). Vinyl chloride monomer and 1,1-difluoroethylene were not acutely hepatotoxic in fed or fasted rats at any concentration tested. Vinyl chloride monomer when administered simultaneously with DCE prevented the injury associated with DCE inhalation in fasted rats. This prevention of injury may be a result of a competitive interaction since the effect was concentration dependent.Keywords
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