Prostaglandins and Platelet Aggregation in Vivo
- 1 January 1970
- journal article
- schattauer gmbh
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 23 (02), 293-298
- https://doi.org/10.1055/s-0038-1654142
Abstract
It was shown previously that prostaglandin E1 (PGE1) inhibits the aggregation of blood platelets in vitro whereas PGF1α does not; in vivo, PGE1 inhibits in rats the action of intravenously injected adenosine diphosphate. Locally administered PGE1 is found in the present experiment to inhibit in rats the formation and growth of platelet thrombi, induced by an electric stimulus in cortical veins. PGF1α appeared to be inactive. The morphology of platelet thrombi induced by an electric stimulus is shown. The probability of a primary role of erythrocytes in the formation of this type of thrombi is discussed.Keywords
This publication has 6 references indexed in Scilit:
- The study of platelet behaviour and its relevance to thrombosisJournal of Atherosclerosis Research, 1967
- Intravascular Haemolysis with Experimentally Produced Vascular ThrombiBritish Journal of Haematology, 1967
- Platelets in Haemostasis and ThrombosisBritish Journal of Haematology, 1967
- A Device for the Production of Well-Defined Lesions of Mesenteric Blood Vessels with Resulting Platelet ThrombiThrombosis and Haemostasis, 1966
- Platelet Clumping in vivoNature, 1963
- Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood PlateletsNature, 1961