A PRELIMINARY STUDY OF THE EFFECT OF NORFENFLURAMINE ON LIPOGENESIS BY HUMAN ADIPOSE TISSUE In vitro
Open Access
- 1 October 1974
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 1 (5), 413-416
- https://doi.org/10.1111/j.1365-2125.1974.tb00279.x
Abstract
1 Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. 2 Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much higher than normal blood levels of the drug. 3 There was no correlation between the degree of inhibition by norfenfluramine in vitro and fat cell size, age or relative weight of the subject. Greater degrees of inhibition were however associated with samples of tissue from patients with higher blood glycerol concentrations and lower blood triglyceride concentrations.Keywords
This publication has 11 references indexed in Scilit:
- The effect of a glucose load on plasma fatty acids and lipolysis in adipose tissue of obese diabetic and non-diabetic patientsDiabetologia, 1974
- A CONTROLLED INVESTIGATION OF THE " GLYCOLYPTIC " ACTION OF FENFLURAMINEThe Lancet, 1972
- The Effect of Drugs on Lipogenesis from Glucose and Palmitate in Human Adipose TissueHormone and Metabolic Research, 1971
- Gas chromatographic measurement of levels of fenfluramine and norfenfluramine in human plasma red cells and urine following therapeutic dosesJournal of Chromatography A, 1970
- EFFECT OF FENFLURAMINE ON BLOOD-LIPIDS IN MANThe Lancet, 1969
- Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogenJournal of Clinical Pathology, 1969
- FENFLURAMINE AND MUSCLE GLUCOSE UPTAKE IN MANThe Lancet, 1968
- A new technique for the investigation of the low-density lipoproteins in health and diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1966
- METABOLISM OF ISOLATED FAT CELLS .I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM + LIPOLYSIS1964
- A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry, 1957