Some Factors Affecting Resistance of Mice to Experimental Histoplasmosis.

Abstract

White Swiss male mice 8 to 12 wks. of age were more susceptible to intraperitoneal inoculations of yeast phase Histoplasma capsulatum than mice of 14 wks. or more. Mice surviving previous sub-lethal infections were more resistant to subsequent challenge 6 wks. later. Vaccination with heat-killed yeast phase antigens resulted in a decrease in the number of fatal infections following massive challenge 6 wks. later.