Abstract
Prediction is very difficult, especially about the future.— Niels BohrMore than 20 years ago, 246 risk factors for coronary heart disease (CHD) had already been identified, and the number continues to grow.1 Advances in genomics and proteomics will provide even more candidate markers to consider for routine assessment in practice. Risk stratification is important because information about the probability of a cardiovascular event in the future can help target therapy and resources to those most likely to benefit. Of the several hundred known correlates of CHD, only a handful have had the staying power to be recommended for . . .

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