THE PHYSIOLOGICAL ACTIVITY OF LAMINARIN SULPHATE

Abstract

When laminarin sulphate was injected intravenously into dogs it acted as an antithrombic agent. As such it was about one-third as potent as heparin. It also showed anticoagulant activity when administered subcutaneously and intramuscularly to the dog.After the intravenous administration of a moderate amount of laminarin sulphate or of heparin to the dog, considerable anticoagulant material passed into the urine. When large oral doses were given to the rat, absorption from the intestine was very small, and much of the material passed into the faeces.When it was given intravenously, laminarin sulphate acted like heparin in clearing alimentary lipaemia in the dog and the rat.