Off‐Signals in Lymphocyte Activation

Abstract

High-dose unresponsiveness to concanavalin A [Con A] affected T [thymus-derived] and B [bone marrow-derived] lymphocytes [mouse] equally, although only T cells were activated by Con A. Activation and inactivation signals are totally unrelated, the latter also lacking target cell specificity. The off-signal caused cell death and is probably biologically unimportant.