Biosynthesis and Processing of a Human Precursor Complement Protein, pro-C3, in a Hepatoma-Derived Cell Line
- 22 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4531), 399-400
- https://doi.org/10.1126/science.7199205
Abstract
A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.This publication has 25 references indexed in Scilit:
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