Abstract
After nasal instillation of poliomyelitis virus in monkeys, there was an appreciable increase of cells in the spinal fluid in some of the animals, within 48 hrs. This rise in cell count was more severe after 96 hrs., even without detectable signs of infection; the globulin was also increased. It is concluded that the cellular change represents a reaction of the nervous system to the virus, and experimental evidence is submitted to show that there is no virus in the spinal fluid itself.