Syndeins: the spectrin-binding protein(s) of the human erythrocyte membrane.
- 1 May 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (5), 2340-2344
- https://doi.org/10.1073/pnas.76.5.2340
Abstract
Two-dimensional tryptic and chymotryptic analyses of all the major bands in a sodium dodecyl sulfate/polyacrylamide gel of the human erythrocyte membrane showed that each band has a characteristic map. Band 2.1 (nomenclature of T. L. Steck) and several polypeptides below this band exhibited similar tryptic and chymotryptic peptide maps and thus appeared to be a family of closely related proteins or degradation products. They all contained a subset of peptides that were accounted for by the peptides from 2 known spectrin-binding fragments. Both fragments derived from 2.1-related proteins. Band 2.1 and its related proteins, named syndeins, bind spectrin and connect it to the erythrocyte membrane.This publication has 20 references indexed in Scilit:
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