Areas of dye-dilution curves sampled simultaneously from central and peripheral sites
- 1 January 1962
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 17 (1), 91-98
- https://doi.org/10.1152/jappl.1962.17.1.91
Abstract
The assumption that the rate of blood flow past the sampling site is constant is basic to the Stewart-Hamilton estimation of cardiac output. Pulsatile flow might be expected to cause random and systematic errors. In this study dye-dilution curves were recorded simultaneously from two or three sites (pulmonary artery, aortic root, thoracic aorta, femoral artery) after injections of dye into the inferior vena cava, right ventricle, pulmonary artery, or left atrium of anesthetized dogs. The color of the indocyanine-protein complex formed after injection of the dye stabilized rapidly. Such stabilization is required for continuous photometric quantitation of dilution curves with juxtaposed injection and sampling sites. Areas of curves from the central circulation did not differ significantly from each other; they averaged 2.5% less than areas of curves recorded simultaneously from the femoral artery. Heart rate had no consistent influence. The large variability in estimates of cardiac output from curves recorded from the pulmonary artery after injection into the right ventricle was diminished with injection farther upstream. Submitted on May 29, 1961Keywords
This publication has 2 references indexed in Scilit:
- Relative Effects of Heart Chambers, Lungs, and Mitral Insufficiency on the Shape of Indicator Dilution CurvesCirculation Research, 1959
- STUDIES ON THE CIRCULATIONAmerican Journal of Physiology-Legacy Content, 1932