Feeding stimulated by very low doses of d-amphetamine administered systemically or by microinjection into the striatum
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 78 (4), 336-341
- https://doi.org/10.1007/bf00433737
Abstract
The effects of d-amphetamine over a wide range of doses (0.125–4.0 mg/kg IP) on rat unconditioned behaviour were examined in the presence of food and water (experiment 1), in their absence (experiment 2) and after microinjection (2.0 μg in 0.5 μl) directly into the striatum (experiment 3). In experiment 1 very low doses (0.125 and 0.25 mg/kg) stimulated the intake of food, but not water, and higher doses produced locomotor hyperactivity, rearing, stereotyped sniffing and anorexia. In experiment 2 all doses, including very low doses (0.125 and 0.25 mg/kg), significantly potentiated locomotor activity. In experiment 3, microinjection into the corpus striatum elicited substantial feeding, but not drinking, locomotor activity or stereotyped behaviour. The results suggest that a single graded facilitative mechanism underlies the effects on food intake and other behavioural effects of amphetamine, as implied by a general hypothesis of amphetamine action proposed in the literature, and that these effects may to a large extent by mediated by forebrain dopamine systems.This publication has 26 references indexed in Scilit:
- Biphasic locomotor response to intra-accumbens dopamine in a nonhuman primatePharmacology Biochemistry and Behavior, 1981
- Blockade of amphetamine-induced locomotor activity and stereotypy in rats by spiroperidol but not by an atypical neuroleptic, thioridazineNeuropharmacology, 1980
- Hyperactivity induced by injection of dopamine into the accumbens nucleus: Actions and interactions of neuroleptic, cholinomimetic and cholinolytic agentsNeuropharmacology, 1979
- Relationship between reward-enhancing and stereotypical effects of psychomotor stimulant drugsNature, 1976
- The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a markerJournal of Comparative Neurology, 1975
- Stimulation of locomotor activity following injection of dopamine into the nucleus accumbensJournal of Pharmacy and Pharmacology, 1973
- Amphetamine as a model for hyperactivity in the ratPhysiology & Behavior, 1973
- Micro-injection of 3H-acetylcholine, 14C-serotonin and 3H-norepinephrine into the hypothalamus of the rat: Diffusion into tissue and ventriclesPhysiology & Behavior, 1971
- Amphetamine Anorexia by Direct Action on the Adrenergic Feeding System of Rat HypothalamusNature, 1968
- Behavioural Stereotypies Induced by Pharmacological AgentsPharmacopsychiatry, 1968