Rate of Metabolism of 9,10-Dimethyl-1,2-Benzanthracene in Newborn and Adult Mice.

Abstract

Summary Determination of the proportion of free 9,10-dimethyl-1,2-benzanthracene remaining in newborn and in adult mice following intraperitoneal injection, revealed that this compound disappeared more quickly from the adult than from the newborn animals. This supports the view that the greater susceptibility of the newborn to tumor induction by this carcinogen is due to longer persistence of the compound in the newborn than in the adult.