Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel
- 15 February 2001
- journal article
- clinical trial
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 19 (4), 1160-1166
- https://doi.org/10.1200/jco.2001.19.4.1160
Abstract
PURPOSE: Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). In addition, metabolism of docetax...Keywords
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