Factors Influencing Collateral Arterial Formation From Pedicles on the Surface of the Hearts of Dogs

Abstract

Experiments were performed in dogs to study factors which influence development of collateral arterial channels from a pedicle applied to the heart. The pedicle contained the mammary artery and mammary vein, and adjacent connective tissue and muscle. Very few collateral channels developed when the mammary artery was allowed to remain open distally. There was a high incidence of thrombosis when the vein was occluded proximally. There was no thrombosis, and many arterial collaterals consistently developed to surrounding adhesions when the distal ends of the mammary artery and vein were ligated, and the proximal ends of each vessel remained attached. Although attempts were made to produce experimental coronary arterial insufficiency, this was believed not to have been satisfactorily accomplished and there were very few collaterals between the mammary and coronary arteries.