5-Hydroxyindoleacetic Acid in the Lumbar Fluid: A Specific Indicator of Spinal Cord Injury
- 9 August 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4150), 527-528
- https://doi.org/10.1126/science.185.4150.527
Abstract
In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.Keywords
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