At the January meeting of the Pittsburgh Dermatological Society my associate, Dr. F. M. Jacob, and I presented a family group of three cases of epidermolysis bullosa. Unusual and perhaps significant facts, developed by investigation during the ensuing year, form the basis of this communication. REPORT OF CASES Three brothers, aged 7, 9 and 17, had been subject to bullous response to minor traumatism since infancy. The parents were native Americans, and consanguinity did not exist. Two other children were normal. There was no evidence of the condition in the parents, and the family history was negative for similar instances. Case 1.— In the boy, aged 17, a tendency to blister formation on slight injury had been noticed by the mother about one year after birth. About the same time the hair fell and was replaced by a fine lanugo type of hair which fell and regrew several times before