Dr, C4, and BF allotypes in juvenile rheumatoid arthritis
Open Access
- 28 November 1984
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 27 (11), 1281-1285
- https://doi.org/10.1002/art.1780271110
Abstract
HLA‐DR, C4, and Bf typing was performed in 99 patients with juvenile rheumatoid arthritis (JRA). DR1 was found with higher frequency in patients with polyarticular JRA than in controls (P < 0.05). DR3 was more common in patients with fever and/or rash than in those without these manifestations (P < 0.05). A significant negative association between JRA and C4A6 (P < 0.05), C4BQ0 (P < 0.0005), and BfF1 (P < 0.05) was found. It is possible that a disequilibrium between DR and C4/Bf genes plays a role in the pathogenesis of JRA.This publication has 19 references indexed in Scilit:
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