Antibiotic Concentration in Human Wound Fluid After Intravenous Administration
- 1 August 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 188 (2), 202-208
- https://doi.org/10.1097/00000658-197808000-00013
Abstract
Since the wound is the most common focus of infection in the surgical patient, adequate levels of antibiotic within the wound are essential. This study examines the concentrations of antibiotic achieved in human wounds. Fluid was collected at timed intervals on the 1st postoperative day from the wounds of 56 patients receiving antibiotics after regional lymph node dissection. Antibiotic concentration was determined by bioassay. Six antibiotics were studied: cephalothin, cefazolin, cephapirin, oxacillin, ampicillin and clindamycin. The cephalosporins and penicillins showed similar patterns of appearance in the wound fluid. The peak level occurred early (1-1 1/2 h) with subsequent slow decrease. Clindamycin produced nearly constant levels in wound fluid. The concentration of each antibiotic in wound fluid surpassed the serum levels after 2.5 h. At the dosages studied each antibiotic produced wound fluid concentrations greater than the MIC [minium inhibitory concentration] for most susceptible organisms. Higher dosages provided higher wound fluid levels. The rate of appearance and the levels achieved should be considered in the choice of antibiotics in the surgical subject.This publication has 14 references indexed in Scilit:
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