THE CHEMICAL FRACTIONATION OF AN ADRENOCORTICOLYTIC DRUG123
- 1 March 1958
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 62 (3), 326-333
- https://doi.org/10.1210/endo-62-3-326
Abstract
It has long been known that technical DDD (2,2-bis (parachlorophenyl) 1,1-dichloroethane) produces adrenal cortical atrophy, but the actual active agent has not been isolated. To isolate this agent, technical DDD was fractionated by recrystallization, oxidation, column chromatography, and chemical and physical analysis into several fractions. Most of the material (83%) was p,p''-DD, 10% was o,p''-DDD, and the remainder consisted of unidentified materials.Keywords
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- SEVERE ADRENAL CORTICAL ATROPHY (CYTOTOXIC) AND HEPATIC DAMAGE PRODUCED IN DOGS BY FEEDING 2,2-BIS(PARACHLOROPHENYL)-1,1-DICHLOROETHANE (DDD OR TDE)1949
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