Activity of moxalactam and cefotaxime alone and in combination with ampicillin or penicillin against group B streptococci
Open Access
- 1 May 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 19 (5), 794-797
- https://doi.org/10.1128/aac.19.5.794
Abstract
The activities of moxalactam and cefotaxime, alone and combined with ampicillin or penicillin, against 40 isolates of group B streptococci were assessed by using the microtiter broth dilution, checkerboard, and time-kill techniques. Penicillin and cefotaxime were bactericidal for all isolates at concentrations of 0.06 micrograms/ml or less. Ampicillin was slightly less active. Moxalactam was bactericidal for all strains at concentrations of 4 to 8 micrograms/ml. The ampicillin- moxalactam combination was partially synergistic for 60% of the isolates tested; the ampicillin-cefotaxime combination was partially synergistic for 35% of these isolates. No instances of antagonism were observed. In time-kill evaluations, ampicillin (3.0 micrograms/ml) and penicillin (0.75 micrograms/ml) effected 2.5 to 3.5 log10 reductions in numbers of colony-forming units. The addition of 4 micrograms of cefotaxime per ml or 8 to 16 micrograms of moxalactam per ml to penicillin or ampicillin did not alter killing kinetics. Moxalactam and cefotaxime neither enhanced nor decreased the activity of ampicillin or penicillin against group B streptococci.This publication has 19 references indexed in Scilit:
- INTRAVENOUS CEFOTAXIME IN CHILDREN WITH BACTERIAL MENINGITISThe Lancet, 1980
- Antimicrobial Synergism--An Elusive ConceptThe Journal of Infectious Diseases, 1979
- HR 756, a New Cephalosporin Active Against Gram-Positive and Gram-Negative Aerobic and Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 1979
- A Pharmacologic Evaluation of Penicillin in Children with Purulent MeningitisNew England Journal of Medicine, 1977
- Coliform meningitis in the newborn.Archives of Disease in Childhood, 1976
- A controlled study of intrathecal antibiotic therapy in gram-negative enteric meningitis of infancyThe Journal of Pediatrics, 1976
- Antibiotic Synergy in Experimental Infection with Pseudomonas. II. The Effect of Carbenicillin, Cephalothin, or Cephanone Combined with Tobramycin or GentamicinThe Journal of Infectious Diseases, 1974
- Suppurative meningitis due to streptococci of lancefield group B: A study of 33 infantsThe Journal of Pediatrics, 1973
- Group B beta hemolytic streptococcal meningitis in infantsThe Journal of Pediatrics, 1973
- Purulent Meningitis in the Neonatal PeriodArchives of Disease in Childhood, 1963