Acute disseminated lupus erythematosus, although a relatively infrequent disease, has been the subject of frequent discussion in dermatologic literature. In 1931 Mook, Weiss and Bromberg1 covered the present knowledge rather thoroughly. Recently Baehr, Klemperer and Schifrin 2 reported and analyzed twenty-three cases. The cause of the disease and its actual mechanism, however, remain a subject of controversy. The fully developed picture of the acute illness, the typical cutaneous eruption and the usual autopsy observations are fairly definite and familiar. It is the earliest phases of the disease that are vague and indefinite. The earliest recognizable symptom is the erythema. There may be preceding or accompanying constitutional symptoms, but these probably are of such general nature that unless the erythema suggests the diagnosis lupus erythematosus will not be suspected. In this connection it is noteworthy that Baehr, Klemperer and Schifrin 2 mentioned cases in which the constitutional manifestations and autopsy