Effect of intravenously administered fat on serum insulin levels

Abstract

The effect of the commercial fat emulsion, Intralipid, on serum insulin levels was investigated in 15 baboons. One group received Intralipid alone, another received only heparin and a third group Intralipid and heparin. Intralipid alone or with heparin resulted in high levels of total lipids and free fatty acids, whereas heparin alone did not cause any change in these parameters. In none of the groups, however, was any change in serum insulin detected, and similarly, hypoglycemia did not develop. These findings are important from the point of view of parenteral nutrition, as this fat emulsion is extensively used for intravenous feeding.