The Central Nervous System and Its Operation in Cardiovascular Control
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension
- Vol. 3 (3), 343-368
- https://doi.org/10.3109/10641968109033670
Abstract
In the intact organism environmental disturbances affecting the circulation often result in simultaneous changes of several groups of peripheral afferents. These elicit characteristic patterns of autonomic activity with distinctive patterns of vagal activity, of regional sympathetic neural activity and of adrenal catecholamine secretion. During simultaneous changes in several groups of afferents the autonomic responses are often non-linear, with the response to one input markedly influenced by the level of the others. When these non-linear interactions involve the central arterial baroreflex pathways the properties of the body's blood pressure system can become greatly altered. With certain combinations of afferents these interactions make it possible for the organism to better withstand large perturbations than it could do through the normal properties of the arterial baroreceptor reflex. The different neuron groups contributing to the CNS autonomic pathways release many different transmitters including noradrenaline or serotonin and changes in reflex properties result from alterations in transmitter release in one or other of the pathways of the particular network. The peripheral arterial baroreceptors become rapidly reset during sustained alterations in blood pressure. Their 'memory' for any given absolute blood pressure is only a few minutes duration. Hence sustained changes in autonomic activity depend on the properties of the CNS either through signals arising from other groups of peripheral receptors, from central 'command' or owing to changes in transmitter release in a given pathway.Keywords
This publication has 37 references indexed in Scilit:
- Baroreceptor function and changes in strain sensitivity in normotensive and spontaneously hypertensive rats.Circulation Research, 1980
- Receptors under pressure. An update on baroreceptors.Circulation Research, 1980
- Direct projection of catecholamine (presumably dopamine)-containing neurons from hypothalamus to spinal cordNeuroscience Letters, 1979
- Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized catsEuropean Journal of Pharmacology, 1977
- Brain amines and models of experimental hypertension.Circulation Research, 1975
- Characteristics of Single Aortic and Right Subclavian Baroreceptor Fiber Activity in Rabbits with Chronic Renal HypertensionCirculation Research, 1973
- Regulation of Blood Pressure by Sympathetic Nerve Fibers and Adrenal Medulla in Normotensive and Hypertensive RatsCirculation Research, 1972
- Effects of haemorrhage on the distribution of the peripheral blood flow in the rabbitThe Journal of Physiology, 1967
- Distribution of peripheral blood flow in primary tissue hypoxia induced by inhalation of carbon monoxideThe Journal of Physiology, 1967
- Local and reflex factors affecting the distribution of the peripheral blood flow during arterial hypoxia in the rabbitThe Journal of Physiology, 1967