Rules for the treatment of neoplastic disease must be based on carefully considered case reports in which complete data on the pathologic picture, clinical development, course, history and end results, to the death of the patient or at least to the end of a five year follow-up, are available to the reporter. The inclusion of cases in which the original diagnosis was made by an unknown pathologist is subject to the criticism that the pathologist may not have been expert in the diagnosis of tumor. The inclusion of cases dating to a previous decade is questionable unless the early slides can be reviewed, since the classification of many tumors has undergone extensive change in recent years. Reports of diagnoses made after biopsy of material taken by means of a punch or by aspiration, without subsequent study of additional tissue, are of questionable value. When the cause of death within a