Localization of α-Melanocyte-Stimulating Hormone in Rat Brain and Pituitary
- 1 April 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (4), 1283-1291
- https://doi.org/10.1210/endo-102-4-1283
Abstract
The distribution of .alpha.-melanocyte-stimulating hormone (.alpha.-MSH) was studied in the rat brain with an immunoperoxidase technique. .alpha.-MSH-containing cells were found in the arcuate nucleus of the hypothalamus. Cells staining for .alpha.-MSH were also localized in the intermediate lobe of the pituitary. .alpha.-MSH-containing nerve fibers extended throughout regions of the hypothalamus, thalamus and midbrain. Two weeks after hypophysectomy, .alpha.-MSH-positive cells and fibers were still present in the brain. .alpha.-MSH of non-pituitary origin is synthesized and stored by neural structures in the rat brain. The detection of .alpha.-MSH by radioimmunoassay in the rat brain and pituitary supports these observations.This publication has 4 references indexed in Scilit:
- Electron microscopic immunohistochemical localization of α‐MSH in the rat brainJournal of Anatomy, 1977
- Immunohistochemical Localization of β-Lipotropic Hormone in the Pituitary GlandEndocrinology, 1977
- EFFECT OF α-MELANOCYTE-STIMULATING HORMONE AND TESTOSTERONE ON CUTANEOUS AND MODIFIED SEBACEOUS GLANDS IN THE RATJournal of Endocrinology, 1976
- The effect of ?-melanocyte stimulating hormone (?-MSH) on the metabolism of blogenlc amines in the rat brainJournal of Neuroscience Research, 1976