Endothelisierung zentraler isolierter Leucomata adhaerentes

Abstract

Among 820 eyes enucleated between 1980 and 1984 and examined histologically there were 132 globes with central corneal-perforations. In ten of these there was a leukoma adherens not in contact with the anterior chamber angle. In all cases it was endothelialized with formation of a new basal lamina. The mean interval between trauma and enucleation of these ten eyes was 22.6 .+-. 16.7 years (0.5-5.2 years), the mean age of the patients at the time of enucleation 50.7 .+-. 22.4 years (15-78 years). Common to all these eyes and therefore of possible pathogenetic importance were: suitable tissue in contact with the corneal endothelium; traumatization of the endothelium and other intraocular structures; intraocular inflammation. The tissue which was pathologically changed and adherent to the cornea served as a "scaffold" for the endothelialization. Healing of the wound caused cell migration and proliferation and, together with intraocular inflammation, secretion of growth factors.