Effect of Ghlorpromazine and Dibenzyline on Bacterial Toxins

Abstract

Chlorpromazine and dibenzyline were tested in mice for their ability to afford protection against toxins derived from Clostridium botulinum, C. perfringens, C. tetani, Aero-bacter aerogenes, Escherichia coli, Pasteurella pestis, Salmonella typhosa. and Shigella dysenteriae. Premedication and treatment with chlorpromazine significantly decreased the mortality from endotoxins derived from E. coli and S. typhosa. Similar treatment with dibenzyline decreased the mortality from toxins derived from S. dysenteriae'' A. aerogenes, P. pestis and C. tetani. Chlorpromazine afforded significant protection when given 2 hours following the injection of endo-toxin derived from E. coli. Premedication was not necessary. Predmedication with clorpromazine increased the mortality from the toxin of C. perfringens: likewise, premedication with dibenzyline increased the mortality from the endotoxin derived from S. typhosa.