Human γ-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7
- 1 August 1985
- journal article
- Published by Springer Nature in Nature
- Vol. 316 (6028), 549-552
- https://doi.org/10.1038/316549a0
Abstract
Three gene families that rearrange during the somatic development of T cells have been identified in the murine genome. Two of these gene families (alpha and beta) encode subunits of the antigen-specific T-cell receptor and are also present in the human genome. The third gene family, designated here as the gamma-chain gene family, is rearranged in murine cytolytic T cells but not in most helper T cells. Here we present evidence that the human genome also contains gamma-chain genes that undergo somatic rearrangement in leukaemia-derived T cells. Murine gamma-chain genes appear to be encoded in gene segments that are analogous to the immunoglobulin gene variable, constant and joining segments. There are two closely related constant-region gene segments in the human genome. One of the constant-region genes is deleted in all three T-cell leukaemias that we have studied. The two constant-region gamma-chain genes reside on the short arm of chromosome 7 (7p15); this region is involved in chromosomal rearrangements identified in T cells from individuals with the immunodeficiency syndrome ataxia telangiectasia and observed only rarely in routine cytogenetic analyses of normal individuals. This region is also a secondary site of beta-chain gene hybridization.Keywords
This publication has 27 references indexed in Scilit:
- Human T-Cell Receptor α-Chain Genes: Location on Chromosome 14Science, 1985
- The human T-cell receptor α-chain gene maps to chromosome 14Nature, 1985
- Limited diversity of the rearranged T-cell γ geneNature, 1985
- Primary structure of human T-cell receptor α-chainNature, 1984
- The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humansCell, 1984
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- Clones with 5q—and Inversion of Chromosome 7 in PHA Stimulated Peripheral BloodScandinavian Journal of Haematology, 1981
- Chromosome 7 in ataxia-telangiectasiaThe Journal of Pediatrics, 1980
- High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasiaMutation Research, 1980
- Assignment of the β-glucuronidase structural gene to the pter→q22 region of chromosome 7 in manCytogenetic and Genome Research, 1978