in vitro Studies with 1-hydroxy-2(1H)pyridinethione

Abstract

An antibacterial and antifungal spectrum for the sodium salt of 1-hydroxy-2 (1H)pyridinethione as well as an assay method for the same is presented. In vitro the substance is partially inactivated by saliva and mucin, by serum at low concentration, but not by human cerebrospinal fluid. The inactivation by saliva, mucin, and serum however may be of relatively minor importance in view of the extraordinarily high activity displayed by this compound.