Pd(II)-Catalyzed Olefination of sp3 C−H Bonds
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- 26 February 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (11), 3680-3681
- https://doi.org/10.1021/ja1010866
Abstract
The first Pd(II)-catalyzed sp3 C−H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding γ-lactams. Notably, this method was effective with substrates containing α-hydrogen atoms and could be applied to effect methylene C−H olefination of cyclopropane substrates.Keywords
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