The same configuration of Ty elements promotes different types and frequencies of rearrangements in different yeast strains
- 1 February 1988
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 211 (2), 272-281
- https://doi.org/10.1007/bf00330604
Abstract
We examined Ty-mediated genomic rearrangements in three related mitotically dividing haploid yeast strains having the same configuration of Ty elements in the CYC1-sup4 interval of chromosome X. Surprisingly, quite different types and frequencies of rearrangements were found in the three strains. In one strain we found only Ty-mediated deletions, which occurred with a frequency of about 1×10-6. Another strain yielded similar deletions, but approximately one-third of these were accompanied by adjacent Ty-mediated inversions. A third strain was found to have an extremely high rate of inversion/reinversion between two of the three Ty elements. This rate was conservatively estimated to be 1.4±0.2×10-2 per cell per generation, which is at least 2 orders of magnitude higher than previously reported values for Ty-mediated rearrangements. These data provide evidence that local regions of the genome can, in some cases, be much more fluid than had been previously believed.This publication has 34 references indexed in Scilit:
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