Intensity-Based Statistical Scorer for Tandem Mass Spectrometry
- 4 January 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 75 (3), 435-444
- https://doi.org/10.1021/ac0258913
Abstract
We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al. (Eng, J. K.; McKormack, A. L.; Yates, J. R. J. Am. Soc. Mass Spectrom.1994, 5, 976−989.).Keywords
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